The fourth and final grand slam on the tennis agenda – the US Open – is set to take place at Flushing Meadows, New York, from 28 August to 10 September and, with two of the big names out of this year’s men’s singles contest, it looks to be an exciting tournament.

Below we look at predictions for the US Open Tennis Tournament.

US Open Tennis Predictions and Betting Odds

Two-time men’s champion, Novak Djokovic, and 2016 winner, Stan Wawrinka, have both announced their withdrawals from the tournament due to injury, which should prove interesting as the contest heats up in the semi’s and finals. Here’s a look at some of the top contenders.

  1. Roger Federer

Without a doubt, this Swiss player is the one to beat. Although his last win at this major was in 2008 (having won the previous four as well), this tennis dynamo looks set to take on anyone as he surges into his final tennis playing years. Fresh off his Wimbledon victory, having claimed a record eight Wimbledon titles and leading the men’s Grand Slam singles titles, Federer will be competing for his sixth US Open title – another record-breaker. He has already won two of the three majors this year and it’s difficult to see this winning streak fizzling out now.

Current betting odds: 12/10

UPDATE: Kevin Anderson in the US Open semi-finals 

  1. Rafael Nadal

The 2010 and 2013 winner is always a top contender, although he did leave Wimbledon in a depressing final-16 exit. He is a 15-time Grand Slam winner, having taken his 10th French Open singles title when he beat Stan Wawrinka in the final, and he also made it to the finals of the Australian Open, losing out to Federer in five sets. When this Spaniard is on form, he’s a tough one to beat.

Current betting odds: 22/10

  1. Marin Cilic

The Croatian’s biggest success was certainly taking the US Open title in 2014 but, at 28 years, he has enough energy to grab another major title, particularly on the turf where he had success previously. By making it to the Wimbledon final this year, the No.6 player worldwide has shown he has what it takes to get there, he just needs to push over that final hurdle.

Current betting odds: 14/1

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  1. Andy Murray

The 2012 US Open winner and two-time Wimbledon title-holder, Murray is very keen on collecting the hardware while he can. However, a nagging hip problem – that should probably see him sit out this one – has inhibited his movement and could seriously affect his game this year.

Current betting odds: 5/1

  1. Juan Martin del Potro

It’s hard not to think of Del Potro’s 2009 US Open win against the almighty Federer as a once-off, but he doesn’t seem to have reached that same magnitude again. However, if the Argentine did it once, there’s no reason why he can’t do it again and he certainly has the ambition to get through.

Current betting odds: 22/1

  1. Venus Williams

One of the veterans of women’s tennis is Venus Williams . At 37 years old, suffering from an autoimmune disease, she would seem an unlikely candidate on paper, but Venus Williams breaks every barrier. She just lost out on her eighth major title to Garbine Muguruza at Wimbledon, but she has adapted her game so well – as all great sportsman do – to suit her age.

Current betting odds: 14/1

  1. Garbine Muguruza

A definite favourite to win, straight from her victory at Wimbledon, this Spaniard has an aggressive game that can see her taking home the US Open title. She beat Serena Williams at the French Open last year and Venus Williams at Wimbledon this year making her the first player in history to defeat both Williams sisters in major finals. That’s impressive. It also bodes very well for the upcoming tournament.

Current betting odds: 6/1

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  1. Maria Sharapova

Finally we will get to see the Russian tennis superstar compete in a Grand Slam tournament again after a year-and-a-half. She was denied her wild card to the French Open following her suspension for using the banned substance, meldonium, and injury saw her sit out Wimbledon, but the US Open has granted her wild card entry. She’s a former world No. 1 player, has five major titles – including the 2006 US Open – and she needs to prove her time off the tennis scene hasn’t dented her game.

Current betting odds: 12/1

  1. Jelena Ostapenko

The 20-year-old rising Latvian tennis superstar defeated Simona Halep at Roland Garros to take her first major title, although she couldn’t seem to keep up the momentum at Wimbledon where she lost to Johanna Konta in the third round. It might be that she peaked too soon, but she’s still young enough to rally. Ostapenka has played in the US Open main draw twice, reaching the second round in 2015 and losing to Petra Kvitova in the first round last year.

Current betting odds: 16/1

  1. Caroline Wozniacki

The Danish tennis star has been a finalist at the US Open twice, reaching the semi-finals stage three other times so this is definitely one place she has remained a constant threat. She has reached four tournament finals this year but has yet to take the title so she’ll be looking to the US Open for that big win.

Current betting odds: 20/1

Please note betting odds quoted are correct at time of publication and are subject to change. View the latest tennis betting odds